The U.S. Food and Drug Administration on Wednesday authorized the use of AstraZeneca's antibody cocktail to prevent COVID-19 infections in individuals with weak immune systems or a history of severe side effects from coronavirus vaccines.
The antibody cocktail, Evusheld, is only authorized for adults and adolescents who are not currently infected with the novel coronavirus and have not recently been exposed to an infected individual, .
The authorization for the therapy, made up of two monoclonal antibodies tixagevimab and cilgavimab, marks a significant step for AstraZeneca, whose widely used COVID-19 vaccine is yet to be approved by U.S. authorities.
AstraZeneca last month had agreed to supply the U.S. government with 700,000 doses of Evusheld, which had earlier shown to cut the risk of people developing any COVID-19 symptoms by 77% in a late-stage trial.
While vaccines rely on an intact immune system to develop targeted antibodies and infection-fighting cells, Evusheld contains lab-made antibodies designed to linger in the body for months to contain the virus in case of an infection.
AstraZeneca's therapy, given in two sequential injections, is designed to last several months to a year.
Although vaccines currently provide the best defence against COVID-19, certain immune-compromised individuals or those who have a history of severe adverse reactions to a vaccine need an alternative prevention option, said Patrizia Cavazzoni, director of the FDA's Center for Drug Evaluation and Research.
However, the FDA added that pre-exposure prevention with Evusheld is not a substitute for vaccination in individuals for whom COVID-19 vaccination is recommended.
Monoclonal antibodies aim to stop COVID-19 from worsening during early, milder stages. Drugmakers such as Eli Lilly, Regeneron, and GlaxoSmithKline with partner Vir make similar therapies.
(Reporting by Manas Mishra and Bhanvi Satija in Bengaluru; Editing by Shounak Dasgupta)
How Iran chooses to respond could determine whether the region spirals further toward all-out war or holds steady at an already destabilizing level of violence.
Millions of Canadians will notice their clocks turn back by one hour on Nov. 3, marking the end of daylight saving time this year.
Giving away used clothes for a second life feels like an act of charity 鈥 and it often is. But it鈥檚 become more complicated. A W5 investigation has discovered allegations that organized crime players are muscling in on charities to access their donation bins.
Recounts will begin Sunday afternoon in two ridings where candidates were separated by fewer than 100 votes following the initial count in the B.C. election.
Not all that glitters is gold, but the value of the precious metal has been surging this year.
A vehicle rammed into a crowd outside a cathedral in Mexico and injured at least 16 people Saturday night, local authorities said.
Former U.S. president Donald Trump has repeatedly referred to CNN anchor Anderson Cooper with a woman's first name in recent days as the Republican presidential nominee focuses his closing message on a hypermasculine appeal to men.
An Israeli attack on Iran damaged facilities at a secretive military base southeast of the Iranian capital that experts in the past have linked to Tehran's onetime nuclear weapons program.
Dodgers superstar Shohei Ohtani partially dislocated his left shoulder during the seventh inning of Saturday's Game 2 of the World Series against the New York Yankees when he tried to steal second base.
Giving away used clothes for a second life feels like an act of charity 鈥 and it often is. But it鈥檚 become more complicated. A W5 investigation has discovered allegations that organized crime players are muscling in on charities to access their donation bins.
Huntsville OPP and the Special Investigations Unit (SIU) are conducting a homicide investigation after three individuals were found dead in a Huntsville neighbourhood Friday evening.
Author and historian Brent Wilson released a new book on New Brunswick airmen from the First World War.
Canadian cities are struggling with the seemingly intractable problem of homelessness and trying various approaches to stop people from sleeping rough, often with mixed results.
When B.C. teenager Amanda Todd sat in front of her computer and detailed the relentless bullying and extortion she'd faced on social media, it sent a shock wave to parents around the world.
Recounts will begin Sunday afternoon in two ridings where candidates were separated by fewer than 100 votes following the initial count in the B.C. election.
How Iran chooses to respond could determine whether the region spirals further toward all-out war or holds steady at an already destabilizing level of violence.
Republican vice presidential nominee JD Vance insisted that Donald Trump鈥檚 attacks on 'the enemy within' were not directed at Democratic Party leaders but dissenting Americans he described as 'far-left lunatics.'
Kamala Harris and Tim Walz will crisscross the United States to visit all seven battleground states in the coming days, part of a final blitz before the Nov. 5 election.
An Israeli attack on Iran damaged facilities at a secretive military base southeast of the Iranian capital that experts in the past have linked to Tehran's onetime nuclear weapons program.
Former U.S. president Donald Trump has repeatedly referred to CNN anchor Anderson Cooper with a woman's first name in recent days as the Republican presidential nominee focuses his closing message on a hypermasculine appeal to men.
Israel attacked military targets in Iran with pre-dawn airstrikes Saturday in retaliation for the barrage of ballistic missiles the Islamic Republic fired on Israel earlier this month. It was the first time Israel's military has openly attacked Iran.
RCMP Commissioner Mike Duheme says there has been a 鈥渟ignificant reduction鈥漷o the public safety threat since six Indian diplomatic officials were expelled from the country last week.
Minister Gary Anandasangaree has apologized to a group of Ontario First Nations for mismanagement of their money over a century ago.
A veteran Ottawa journalist is firing back against what he says are "entirely false" claims by a former Conservative cabinet minister that he acted as a Russian agent.
Whole Foods Market is joining the growing list of brands whose frozen waffles have been recalled in Canada this week because of possible listeria contamination.
Angela Salvatore had been away from her father's hospital bedside for just over an hour when she says she got a frantic call from a nurse, pleading with her to calm him down.
A U.S.-based food manufacturer that supplies frozen waffles to major grocery chains across North America has launched a voluntary recall over concerns its products carry the potential for illness.
The U.S. Bureau of Land Management has hosted the online competition since 2019 to raise awareness about the bat's ecological importance.
Law enforcement agencies across the U.S. are cracking down on a troubling spread of child sexual abuse imagery created through artificial intelligence technology 鈥 from manipulated photos of real children to graphic depictions of computer-generated kids.
The search for a popular tortoise that went missing from his home in Piedmont is over after his owner said he came home.
Lizzo has taken a rather silly reference to her on a recent 'South Park' episode and elevated it to a hilarious Halloween costume.
'I鈥檓 not here as a celebrity, I鈥檓 not here as a politician. I鈥檓 here as a mother,' Beyonc茅 said at a campaign rally for Kamala Harris.
Phil Lesh, a classically trained violinist and jazz trumpeter who found his true calling reinventing the role of rock bass guitar as a founding member of the Grateful Dead, died Friday at age 84.
Five things to watch for in the Canadian business world in the coming week: Bank of Canada, GDP figures, and results for Enbridge, Parkland, and Imperial Oil.
Natural gas producers in Western Canada have white-knuckled it through months of depressed prices, with the expectation that their fortunes will improve when LNG Canada comes online in the middle of next year.
Bank of Canada governor Tiff Macklem says the world has become more prone to supply shocks which create more risks to inflation, but the central bank is in a better place to deal with them now that inflation is under control.
Two witches talk about their daily rituals, from spell-casting to TikTok posting, and how they discovered their magic.
New Brunswicker Jillea Godin鈥檚 elaborate cosplay pieces attract thousands to her online accounts, as well as celebrities requesting their own pieces.
Archeologists have uncovered a tiny house in Pompeii that is filled with elaborate 鈥 and sometimes erotic 鈥 frescoes, further revealing the ornate way in which Romans decorated their homes.
The Indiana Fever fired coach Christie Sides on Sunday, the organization announced.
Real Madrid, the Spanish league and the local government condemned racist insults against Barcelona's player Lamine Yamal during Saturday's 'El Clasico.'
Shortly after failing to capitalize on a late two-man advantage, the Winnipeg Jets got a second chance and didn't waste it.
Based on initial appearances, there are signs indicating the automobile industry is in healthy shape 鈥 for now.
A town in southern Alberta will be one of the first to let golf carts be driven on select roads as part of a provincial pilot program.
An increased risk of fire has prompted the recall of thousands of Honda hybrid vehicles in Canada.
A new resident at a Manitoba animal rescue has waddled her way into people's hearts.
Hundreds of people ran to the music of German composer and pianist Beethoven Wednesday night in a unique race in Halifax.
He is a familiar face to residents of a neighbourhood just west of Roncesvalles Avenue.
A meteor lit up our region's sky last night 鈥 with a large fireball shooting across the horizon over Lake Erie at around 7:00 p.m.
Residents of Ottawa's Rideauview neighbourhood say an aggressive wild turkey has become a problem.
A man who lost his life while trying to rescue people from floodwaters, and a 13-year-old boy who saved his family from a dog attack, are among the Nova Scotians who received a medal for bravery Tuesday.
A newly minted Winnipegger is hoping a world record attempt will help bring awareness for the need for more pump track facilities in the city.
A Springfield, Ont. man is being hailed a 'hero' after running into his burning home to save his two infant children.
Hortense Anglin was the oldest graduate to make her way across the platform at York University's Fall Convocation ceremony this week. At the age of 87, she graduated with an Honours degree in Religious Studies.
Recounts will begin Sunday afternoon in two ridings where candidates were separated by fewer than 100 votes following the initial count in the B.C. election.
Three properties in the Deep Cove area of North Vancouver were ordered to evacuate Saturday night.
Arshdeep Bains got a solid vote of confidence before suiting up for his hometown Vancouver Canucks on Saturday.
Ontario is moving to extend a 5.7-cent cut to the provincial gas tax until next summer.
More Torontonians will be able to get their doses of a new COVID-19 vaccine on Monday. Here's what to know.
Federal Transport Minister Anita Anand is requesting a meeting with her provincial counterpart to tackle the rising issue of re-Vinning and fraudulent vehicle registrations.
A day of hope turned into a day of despair for the Saskatchewan Roughriders on Saturday.
One person is in hospital with potentially life-threatening injuries after a crash between a motorized scooter and a vehicle.
Following an investigation, four Albertans have been charged in relation to the murder of a Manning, Alberta resident.
Transportation for students in Renfrew County will be back in service for the first time this year starting on Monday.
CTVNewsOttawa.ca looks at things to do in Ottawa and eastern Ontario this weekend.
Two people are facing charges after a "high-risk" traffic stop on Highway 401 near Prescott, according to provincial police.
Seven people were hit by a vehicle during a brawl between a group of individuals that got out of hand in Montreal.
The dockworkers at the Port of Montreal are on strike on Sunday, as they had announced, due to the impasse in negotiations for the renewal of their collective agreement.
Montreal police (SPVM) are investigating an alleged case of voyeurism on the metro involving an 18-year-old woman, with video footage of the incident now circulating on social media
Lac La Biche RCMP took a man they believed to be armed and dangerous into custody Sunday morning.
Following an investigation, four Albertans have been charged in relation to the murder of a Manning, Alberta resident.
A worker was killed on the job in Stony Plain on Tuesday, one day after a worker was killed in northwest Edmonton.
With a provincial election announcement expected Sunday, Nova Scotia鈥檚 political party leaders have announced events.
Canadian cities are struggling with the seemingly intractable problem of homelessness and trying various approaches to stop people from sleeping rough, often with mixed results.
Author and historian Brent Wilson released a new book on New Brunswick airmen from the First World War.
Winnipeg police have arrested and charged a man believed to be connected with an assault at a University of Manitoba dorm room.
The mystery of a 100-year-old letter sent from Manitoba to Ireland is slowly unraveling thanks to the work of one amateur sleuth.
Pop culture connoisseurs made their way by the masses to the fourth annual Winnipeg Comiccon this weekend.
No injuries have been reported in connection to a house fire in Regina鈥檚 North Central neighbourhood Saturday evening.
The Calgary Stampeders picked up their first road victory of the season Saturday, defeating the Saskatchewan Roughriders 27-12 in the final regular-season game of the year.
Saskatchewan was one of the regions that experienced one of the hottest heat waves in Canada this summer, according to Environment and Climate Change Canada (ECCC).
Police are investigating after a Guelph home was broken into early Saturday morning.
Fire crews responded to a fire at a Waterloo waste management site Friday evening.
Trillium Care in Norwich, Ont. has announced they will be closing their facilities, citing 鈥渁n emergency lack of financial resources necessary to sustain daily operations.鈥
Saskatoon fire crews responded to a major house fire on the 400 block of 24th Street West on Friday evening.
The Saskatoon Police Service is cautioning residents about a phone scam involving fraudulent lottery claims.
The Calgary Stampeders picked up their first road victory of the season Saturday, defeating the Saskatchewan Roughriders 27-12 in the final regular-season game of the year.
One person is dead after a crash involving an all-terrain vehicle (ATV) in eastern Ontario. Frontenac County OPP responded to a crash involving an ATV on a trail in Ardoch, Ont., 30 km north of Sharbot Lake.
Huntsville OPP and the Special Investigations Unit (SIU) are conducting a homicide investigation after three individuals were found dead in a Huntsville neighbourhood Friday evening.
Former U.S. president Donald Trump has repeatedly referred to CNN anchor Anderson Cooper with a woman's first name in recent days as the Republican presidential nominee focuses his closing message on a hypermasculine appeal to men.
Trillium Care in Norwich, Ont. has announced they will be closing their facilities, citing 鈥渁n emergency lack of financial resources necessary to sustain daily operations.鈥
Two new interchanges have opened in St. Thomas, Ont. but one main artery is set to close Monday for construction.
Identical twins Chase and Sydney Brown talk on the phone every night. That was until this week, when, for the first time ever, the brothers will play against each other on a football field.
Huntsville OPP and the Special Investigations Unit (SIU) are conducting a homicide investigation after three individuals were found dead in a Huntsville neighbourhood Friday evening.
Bracebridge OPP are searching for two suspects who allegedly broke into a Gravenhurst jewelry store early Saturday morning.
A man was charged after allegedly crashing into a parked OPP cruiser in Tay Township early Sunday morning.
Police have charged a man with robbery after an incident Saturday afternoon in Chatham.
Donated and reusable household items piled up in trucks outside the Windsor Family Credit Union Centre Saturday afternoon in an effort to divert goods from the landfill.
Chatham-Kent Police Service (CKPS) has charged a man after they were contacted over a disturbance at a home on Sheldon Avenue in Chatham.
Recounts will begin Sunday afternoon in two ridings where candidates were separated by fewer than 100 votes following the initial count in the B.C. election.
There were tense moments at a ferry terminal outside Victoria, B.C., on Friday after the lion鈥檚 share of standby spots on an early sailing were claimed by 鈥渁ssured loading鈥 passengers 鈥 leaving regular customers who had been waiting for hours out of luck.
Hulitan Early Years Centre is a brand new, 48-seat childhood learning centre in Colwood. It was built to support Indigenous children throughout the capital region.
More than two years after Alannah Brown and Douglas Barker were found dead north of Penticton, police are asking for help identifying a vehicle they believe was associated with the crime.
Dave Lindsey began growing giant pumpkins to bring a bit of magic to his grandkids' Halloween.
A U.S. District Court judge in Montana has sentenced a 27-year-old man from Kelowna, B.C., to 18 months in prison for using fake names to buy guns with the aim of selling them in Canada.
A tentative agreement has been reached between the City of Lethbridge and more than 900 employees belonging to CUPE Local 70.
The Hurricanes will be happy to be back home in Lethbridge Saturday night after losing their third in a row on the road Friday night, a 4-1 decision to the Broncos in Swift Current.
About 15,000 students are enrolled at Lethbridge鈥檚 post-secondary schools, and now the city is working with those schools to try to find ways to get them s to stick around a while.
Creditors have moved to take ownership of most of the properties in northern Ontario owned by a group of 11 insolvent companies.
Ontario Provincial Police have been cleared in the case of a woman who crashed her vehicle intentionally while she was high on drugs and fled into the woods earlier this year.
The union that represents hospital workers across the province is used a symbol from Greek mythology Friday in Espanola to drive home its campaign about the perils of privatization in health care.
Teams are facing off in a new eastern Newfoundland hockey league aiming to bring competitive play 鈥 and a few extra years on the ice 鈥 for young women in the province.
Investigators found the remains of a 77-year-old American man on Wednesday at the scene of a fire that destroyed a hotel in western Newfoundland earlier on the weekend.
Police in western Newfoundland say a 77-year-old man visiting the province from Kansas is missing after a fire at a hotel in Deer Lake, N.L.
The Shopping Trends team is independent of the journalists at 愛污传媒. We may earn a commission when you use our links to shop.聽Read about us.
