A World Health Organization (WHO) advisory group on Thursday recommended that this year's COVID-19 booster shots be updated to target one of the currently dominant XBB variants.
New formulations should aim to produce antibody responses to the XBB.1.5 or XBB.1.16 variants, the advisory group said, adding that other formulations or platforms that achieve neutralizing antibody responses against XBB lineages could also be considered.
The group suggested no longer including the original COVID-19 strain in future vaccines, based on data that the original virus no longer circulates in human beings and shots targeting the strain produce "undetectable or very low levels of neutralizing antibodies" against currently circulating variants.
COVID-19 vaccine makers like Pfizer/BioNtech, Moderna Inc and Novavax Inc are already developing versions of their respective vaccines targeting XBB.1.5 and other currently circulating strains.
The U.S. Food and Drug Administration is also set to hold a meeting of outside experts in June to discuss the strain compositions of COVID-19 shots for later this year; vaccine manufacturers will be expected to update their shots once the strains are selected.
The bivalent booster shots developed and distributed last year targeted two different strains - the Omicron variant as well as the original virus.
WHO's advisory group, which recommends if changes are needed to the composition of future COVID-19 shots, said currently approved vaccines should continue to be used in accordance with the agency's recommendations.
In late March, WHO had revised its COVID-19 vaccination recommendations and suggested healthy children and adolescents might not necessarily need a shot, but older and high-risk groups should get a booster between six and 12 months after their last vaccine.
The latest recommendations come about two weeks after WHO ended the global emergency status for COVID-19.
An organization that represents clothing recyclers says they鈥檙e frustrated after a W5 investigation found a fake charity and some violent players connected to organized crime have been muscling in on the clothing donation bin industry, and is calling for governments to do more.
Marred by several delays, the trial of alleged human traffickers Lauriston and Amber Maloney is underway Monday in a Bradford courtroom, with both entering a not guilty plea.
A group of Cape Breton firefighters are apologizing after four people showed up at a Halloween dance dressed in what appeared to be Ku Klux Klan costumes.
Conservative Leader Pierre Poilievre says if his party forms government, it will scrap the federal sales tax on new homes sold for less than $1 million and push provinces to do the same.
A recall has been issued for gummy candies due to pieces of wood, according to the Canadian Food Inspection Agency.
A manhunt is underway in northern Austria after a hunter allegedly fatally shot two people and fled the scene, local police said Monday.
Canadian doctors are calling for employers and schools not to require sick notes when it comes to short-term minor illnesses.
Here's how retirees will get their funds from the federal benefit.
Colin Farrell took time out from his acting schedule on Sunday to complete the Dublin Marathon 鈥 while pushing an old friend in a wheelchair.
A group of Cape Breton firefighters are apologizing after four people showed up at a Halloween dance dressed in what appeared to be Ku Klux Klan costumes.
Marred by several delays, the trial of alleged human traffickers Lauriston and Amber Maloney is underway Monday in a Bradford courtroom, with both entering a not guilty plea.
A major amusement park is part of Ontario's grand vision to turn the Niagara region into Las Vegas north, but Marineland may not fit the bill, the provincial tourism minister says.
Epcor says it has removed more than 20,000 goldfish from an Edmonton stormwater pond.
A minor earthquake shook off the coast of B.C. Monday morning, which registered at a magnitude of 4.1, according to federal officials.
Candidates across Saskatchewan have made their final pitches to potential voters as the 2024 campaign comes to a close and election day arrives.
When U.S. President Joe Biden entered a voting booth in Delaware on Monday to cast his early ballot for Vice President Kamala Harris, it wasn't necessarily the moment for which he'd been planning a few months ago.
Iranian-German prisoner Jamshid Sharmahd, who was kidnapped in Dubai in 2020 by Iranian security forces, has been executed in Iran after being convicted on terror charges disputed by his family, the country's judiciary reported Monday.
Israel's parliament is scheduled to vote Monday on a pair of bills that would effectively sever ties with the UN agency responsible for distributing aid in Gaza, strip it of legal immunities and restrict its ability to support Palestinians in east Jerusalem and the West Bank.
North Korea has sent about 10,000 troops to Russia to train and fight in Ukraine within 'the next several weeks,' the Pentagon said Monday, in a move that western leaders say will intensify the almost three-year war and jolt relations in the Indo-Pacific region.
An investigation by French newspaper Le Monde found that the highly confidential movements of U.S. President Joe Biden, presidential rivals Donald Trump and Kamala Harris and other world leaders can be easily tracked online through a fitness app that their bodyguards use.
A Louisiana state trooper pleaded no contest Monday to significantly reduced charges that spare him jail time in the deadly 2019 arrest of Black motorist Ronald Greene, the first conviction of any kind in a prolonged police brutality case that once prompted national outrage.
Another week, another raft of imminent challenges to Justin Trudeau's leadership of both the country and the Liberal Party.
Conservative Leader Pierre Poilievre says if his party forms government, it will scrap the federal sales tax on new homes sold for less than $1 million and push provinces to do the same.
RCMP Commissioner Mike Duheme says there has been a 鈥渟ignificant reduction鈥漷o the public safety threat since six Indian diplomatic officials were expelled from the country last week.
Transplant experts are seeing a spike in people revoking organ donor registrations, their confidence shaken by reports that organs were nearly retrieved from a Kentucky man mistakenly declared dead.
Canadian doctors are calling for employers and schools not to require sick notes when it comes to short-term minor illnesses.
A recall has been issued for gummy candies due to pieces of wood, according to the Canadian Food Inspection Agency.
An investigation by French newspaper Le Monde found that the highly confidential movements of U.S. President Joe Biden, presidential rivals Donald Trump and Kamala Harris and other world leaders can be easily tracked online through a fitness app that their bodyguards use.
A British man who used artificial intelligence to create images of child abuse was sent to prison for 18 years on Monday.
Renowned Canadian author Margaret Atwood, who is currently writing her memoir, said in an interview that she is too old to be worried about the rise of artificial intelligence and described herself as still having a 'good time' writing.
Adele and Celine Dion were each brought to tears after an emotional interaction during Adele's concert at The Colosseum at Caesars Palace in Las Vegas.
Colin Farrell took time out from his acting schedule on Sunday to complete the Dublin Marathon 鈥 while pushing an old friend in a wheelchair.
Victor Garber got teary-eyed when he walked into a brunch in his honour Sunday in London, Ont.
Cybersecurity firm CrowdStrike said on Monday it sued Delta Air Lines in U.S. District Court in Georgia after a faulty software update prompted a global outage in July.
Volkswagen has informed employee representatives that it wants to close at least three plants in Germany, the head of the company's works council said Monday.
American Airlines is testing a new technology at three airports across the U.S. during the boarding process that aims to cut down on passengers who try to cut the line.
One bar in Tokyo has been trying to reintroduce to locals and visitors alike a taste of doburoku, one of the oldest and most controversial drinks in Japanese history.
British chef Jamie Oliver is asking for help to solve the mystery of a missing award-winning cheddar, worth US$390,000.
With jaw-dropping big wall ascents and a life packed with adrenaline and adventure, climber Tommy Caldwell has had a career worthy of 鈥 and captured by 鈥 a feature film.
Dwyane Wade鈥檚 status as a Miami Heat legend was further cemented on Sunday as the franchise unveiled an eight-foot statue of the three-time NBA champion.
San Francisco 49ers star Nick Bosa crashed his teammates' postgame interview on Sunday to show his support for former U.S. president Donald Trump in the 2024 presidential election with a hat emblazoned with Trump's slogan: Make America Great Again.
Leon Draisaitl scored his second goal of the game 18 seconds into overtime and the Edmonton Oilers beat the Detroit Red Wings 3-2 on Sunday night.
Volkswagen has informed employee representatives that it wants to close at least three plants in Germany, the head of the company's works council said Monday.
A 17-year-old Ottawa driver was caught speeding nearly 90 km/h over the speed limit on Highway 417.
Based on initial appearances, there are signs indicating the automobile industry is in healthy shape 鈥 for now.
Epcor says it has removed more than 20,000 goldfish from an Edmonton stormwater pond.
Witches and warlocks have been flocking to New Brunswick waterways this month, as a new Halloween tradition ripples across the province.
New Brunswicker Jillea Godin鈥檚 elaborate cosplay pieces attract thousands to her online accounts, as well as requests from celebrities for their own pieces.
A new resident at a Manitoba animal rescue has waddled her way into people's hearts.
Hundreds of people ran to the music of German composer and pianist Beethoven Wednesday night in a unique race in Halifax.
He is a familiar face to residents of a neighbourhood just west of Roncesvalles Avenue.
A meteor lit up our region's sky last night 鈥 with a large fireball shooting across the horizon over Lake Erie at around 7:00 p.m.
Residents of Ottawa's Rideauview neighbourhood say an aggressive wild turkey has become a problem.
A man who lost his life while trying to rescue people from floodwaters, and a 13-year-old boy who saved his family from a dog attack, are among the Nova Scotians who received a medal for bravery Tuesday.
An ongoing count of absentee ballots in British Columbia's election has seen the NDP cut the B.C. Conservatives' lead in a key riding to just four votes.
Police with the British Columbia Highway Patrol have arrested a 28-year-old man after 73 kilograms of cocaine were allegedly found inside a vehicle near the resort city of Revelstoke.
More than a week after a man was set to return from his hiking trip in northern B.C., police have released more information in hopes of advancing the missing person鈥檚 case.
New home sales in the Greater Toronto Area remained sluggish last month, but a new report suggests that the market is now primed for buyers following four consecutive interest rate cuts.
Peel Regional Police say investigators have arrested five suspects and seized dozens of guns and illegal devices used to convert firearms into automatic weapons.
An organization that represents clothing recyclers says they鈥檙e frustrated after a W5 investigation found a fake charity and some violent players connected to organized crime have been muscling in on the clothing donation bin industry, and is calling for governments to do more.
RCMP say a Medicine Hat man was killed in a collision between an SUV and a motorcycle in southeast Alberta on Sunday evening.
Shania Twain is coming to Calgary to help kick off Stampede. The Grammy-award-winning singer will be playing the Saddledome on July 5, 2025, to mark the start of 鈥淭he Greatest Outdoor Show on Earth.鈥
Calgary鈥檚 Mission Bridge will be closed to motorists for several months as city crews complete rehabilitation work.
Grief counsellors are at Perth and District Collegiate Institute in Perth, Ont. today, as family, friends and the community mourn the death of 15-year-old Reese Stanzel.
Suspended Ottawa lawyer James Bowie has been ordered to pay $235,000 in damages to a former client after he repeatedly suggested she pay for his legal services with oral sex and released personal details about her online after the allegations were reported by 愛污传媒 Ottawa.
Municipalities across Ontario are facing a cost increase for provincial police services next year, including the Town of Arnprior, which will see a 21 per cent increase for the OPP.
The National Director of Youth Protection, Catherine Lemay, resigned at the request of the minister responsible for social services, Lionel Carmant, after institutional scandals.
The Parti Quebecois (PQ) said on Monday that if Canada continues its immigration policy, independence is the only way to protect its public services.
At a general meeting on Sunday, longshoremen at the Port of Montreal decided to hold another partial strike, this time indefinitely.
Epcor says it has removed more than 20,000 goldfish from an Edmonton stormwater pond.
Police are looking for help identifying an armed robber in a costume.
A warrant has been issued for an Edmonton man in connection with a $2.3 million drug bust earlier this month.
A group of Cape Breton firefighters are apologizing after four people showed up at a Halloween dance dressed in what appeared to be Ku Klux Klan costumes.
The Saint John Police Force is asking for the public鈥檚 help in locating a man wanted on a Canada-wide warrant in connection with a shooting incident in the city over the weekend.
Nearly a month earlier than last year, we have our first snowfall warning of the season issued in the Maritimes.
Three youths were arrested after a senior was shot in the head with a BB gun early Monday morning.
Manitoba Premier Wab Kinew has honoured first responders for their actions following a fiery bus crash on the Trans-Canada Highway last year that killed 17 people.
A North End home went up in flames early Monday morning.
Candidates across Saskatchewan have made their final pitches to potential voters as the 2024 campaign comes to a close and election day arrives.
With multiple polls suggesting a tight race to the finish for Saskatchewan's major political parties 鈥 here are the ridings where some extra attention may be required.
Election day has arrived in Saskatchewan. With it, the last wave of voters prepare to cast their ballots and decide who will form government in the province.
What role does ideology play in the sentencing of the man who pleaded guilty to four charges in an attack at the University of Waterloo?
The Guelph Police Service is planning to dedicate more resources to ensuring public safety in the city鈥檚 downtown area as part of an ongoing initiative.
Police say just before 5 p.m. Friday, the suspects went to an address near Dawson Road and Shelldale Crescent and banged on the door.
Candidates across Saskatchewan have made their final pitches to potential voters as the 2024 campaign comes to a close and election day arrives.
With multiple polls suggesting a tight race to the finish for Saskatchewan's major political parties 鈥 here are the ridings where some extra attention may be required.
A construction worker who was robbed, shot and left for dead last week remains in a Saskatoon hospital awaiting more surgeries.
Ontario Premier Doug Ford in Sudbury on Monday afternoon to make an announcement at a wastewater facility.
Two people were busted in Nipissing First Nation trying to use fake money to buy machinery, Anishinabek Police Service says.
Former U.S. president Donald Trump has repeatedly referred to CNN anchor Anderson Cooper with a woman's first name in recent days as the Republican presidential nominee focuses his closing message on a hypermasculine appeal to men.
A home in Londesborough has been severely damaged following an early morning fire. Central Huron fire crews were called to the home on Sarah Street around 5:30 a.m.
London Health Sciences Centre (LHSC) and St. Joseph鈥檚 hospitals are reintroducing masking guidelines. Starting Thursday, patients at both hospitals with a fever or respiratory symptoms will be required to wear a mask except in inpatient rooms.
According to police, The Uniformed Division Special Constable Program, will have the special constables, "Working closely with patrol operations to ensure the safety and security of the London community."
Marred by several delays, the trial of alleged human traffickers Lauriston and Amber Maloney is underway Monday in a Bradford courtroom, with both entering a not guilty plea.
Huntsville OPP and the Special Investigations Unit (SIU) are conducting a homicide investigation after three individuals were found dead in a Huntsville neighbourhood Friday evening.
Emergency crews battled a house fire in Huntsville that claimed the life of one pet on Monday.
Windsor police officers are asking for the public鈥檚 help to identify two suspects related to the death of a 69-year-old man in south-central Windsor.
A man is facing several charges after a five-hour standoff with Windsor police over the weekend.
A recall has been issued for gummy candies due to pieces of wood, according to the Canadian Food Inspection Agency.
An ongoing count of absentee ballots in British Columbia's election has seen the NDP cut the B.C. Conservatives' lead in a key riding to just four votes.
Police with the British Columbia Highway Patrol have arrested a 28-year-old man after 73 kilograms of cocaine were allegedly found inside a vehicle near the resort city of Revelstoke.
A minor earthquake shook off the coast of B.C. Monday morning, which registered at a magnitude of 4.1, according to federal officials.
More than two years after Alannah Brown and Douglas Barker were found dead north of Penticton, police are asking for help identifying a vehicle they believe was associated with the crime.
Dave Lindsey began growing giant pumpkins to bring a bit of magic to his grandkids' Halloween.
A U.S. District Court judge in Montana has sentenced a 27-year-old man from Kelowna, B.C., to 18 months in prison for using fake names to buy guns with the aim of selling them in Canada.
RCMP say a Medicine Hat man was killed in a collision between an SUV and a motorcycle in southeast Alberta on Sunday evening.
A tentative agreement has been reached between the City of Lethbridge and more than 900 employees belonging to CUPE Local 70.
The Hurricanes will be happy to be back home in Lethbridge Saturday night after losing their third in a row on the road Friday night, a 4-1 decision to the Broncos in Swift Current.
Ontario Provincial Police say three people have been charged with arson following a fire at a Sioux Lookout apartment building Friday night.
Last week, tariffs surrounding Chinese steel and aluminum products went into effect and stakeholders in northern Ontario and abroad say it's good news.
A female athlete from Sault Ste. Marie, Ont., achieved two big goals at the 2024 World Triathlon championships in Spain last weekend.
Teams are facing off in a new eastern Newfoundland hockey league aiming to bring competitive play 鈥 and a few extra years on the ice 鈥 for young women in the province.
Investigators found the remains of a 77-year-old American man on Wednesday at the scene of a fire that destroyed a hotel in western Newfoundland earlier on the weekend.
Police in western Newfoundland say a 77-year-old man visiting the province from Kansas is missing after a fire at a hotel in Deer Lake, N.L.
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