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Coronavirus

    • Pfizer says COVID treatment Paxlovid fails to prevent infection of household members

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    Pfizer on Friday said a large trial found that its COVID-19 oral antiviral treatment Paxlovid was not effective at preventing coronavirus infection in people living with someone who had been exposed to the virus.

    The trial enrolled 3,000 adults who were household contacts exposed to an individual who was experiencing symptoms and had recently tested positive for COVID-19. They were either given Paxlovid for five or 10 days or a placebo.

    Those who took the five-day course were found to be 32 per cent less likely to become infected than the placebo group. That rose to 37 per cent with 10 days of Paxlovid. However, the results were not statistically significant and thus possibly due to chance.

    Pfizer said safety data in the trial was consistent with previous studies, which had shown the pills to be nearly 90 per cent effective at preventing hospitalization or death in COVID patients at high risk of severe illness when taken for five days shortly after symptom onset.

    鈥淲hile we are disappointed in the outcome of this particular study, these results do not impact the strong efficacy and safety data we鈥檝e observed in our earlier trial for the treatment of COVID-19 patients," Pfizer Chief Executive Albert Bourla said in a statement.

    Pfizer said Paxlovid, which consists of two different antiviral drugs, is currently approved or authorized for conditional or emergency use in more than 60 countries across the globe to treat high-risk COVID-19 patients.

    Sales of Paxlovid, part of a class of drugs known as protease inhibitors, are projected to reach $24 billion this year, according to Wall Street forecasts compiled by Refinitiv.

    Shares of Pfizer, which fell 3 per cent in regular trading, were down another 1 per cent at $48.53 after hours.

    (Reporting By Deena Beasley. Editing by Bill Berkrot)

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    • The eight sons of Richard and Sarah Harvie from Gormanville, N.S., are believed to be the most siblings from one family, from either North America or the British Commonwealth, to serve in World War II.

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    • A five-seat sushi counter located inside another restaurant is the latest Vancouver eatery to receive a Michelin star.

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    • A Pickering, Ont., student going to college to be a mechanic is shocked the engine in his two-year-old car will not be repaired under warranty after the dealership claimed he had been 'over-revving' the engine.

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    Chantal Kreviazuk is set to return to Winnipeg to mark a major milestone in her illustrious musical career.

    From the beaches of Cannes to the bustling streets of New York City, a new film by a trio of Manitoba directors has toured the international film festival circuit to much pomp and circumstance.

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    • The calculus of predicting an election and identifying its key battlegrounds is complex enough in any race, but observers of the British Columbia poll this month are facing a pair of unknown quantities that make the math even more confounding.

    • One person is dead after the driver of a pickup truck hit a bench where two people were waiting for the bus in Surrey Saturday afternoon, police have confirmed.

    • A massive fire broke out in downtown Langley Saturday morning, destroying a restaurant and forcing several other businesses to close.

    • The Ontario Science Centre is set to launch two temporary satellite locations in other parts of Toronto, which could let visitors access some of its interactive exhibits while a full interim location remains at least a year away, 愛污传媒 has learned.

    • Leo Campana's stoppage-time goal gave Inter Miami a 1-0 win and left Toronto FC's playoff hopes hanging by a thread Saturday.

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    • Nanton RCMP are on scene Sunday morning at a serious single-vehicle crash at the intersection of Highway 533 and Range Road 118.

    • Ontario Provincial Police say a man has died after striking obstacles on the St. Lawrence River while driving a personal watercraft.

    • The annual RBC Race for Kids raised $830,000 in support of a historic redevelopment for eastern Ontario's largest children's hospital.

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    • The Saskatchewan Roughriders have clinched a playoff spot thanks to a win over the Edmonton Elks.

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